[Surgical treatment of patients with acute pulmonary tuberculosis].

The immediate and late outcomes of treatment of acute pulmonary tuberculosis with and without surgical treatments (337 and 271 patients, respectively) were analyzed. The vast majority of patients in both groups were those with caseous pneumonia and fibrocavernous tuberculosis complicated by caseous pneumonia. A complete clinical effect was achieved in 14% of non-operated patients at their discharge, with a hospital mortality of 15.

[Leukinferon in combined therapy for acute pulmonary tuberculosis].

Experiments on 140 CBA and C57BL/6 mice and studies of 163 patients with acute pulmonary tuberculosis have indicated that leukinferon has a immunomodulating effect on morphological reactions in the lung and on the clinical course of the disease. They have shown that leukinferon plays an important role in the activation of exudate macrophages and in the acceleration of their differentiation in experimental tuberculosis and that there is a rapid elimination of Mycobacterium tuberculosis from the involved organs without production of the L-forms of the causative agent when immunomodulation is used. At months 2-3, the patients with acute pulmonary tuberculosis showed the accelerated processes of detoxification, abacillation, infiltrate resolution, and decay cavity closure during hemo- and immunomodulation with the normalized production of cytokines (gamma-interferon and tumor necrosis factor-alpha).

An unsupervised automatic method for sorting neuronal spike waveforms in awake and freely moving animals.

The present study introduces an approach to automatic classification of extracellularly recorded action potentials of neurons. The classification of spike waveform is considered a pattern recognition problem of special segments of signal that correspond to the appearance of spikes. The spikes generated by one neuron should be recognized as members of the same class.

[Plasmapheresis in the complex treatment of patients with acutely progressive pulmonary tuberculosis].

The efficiency of plasmapheresis versus routine methods of detoxification in the complex treatment was compared in 100 patients with acutely progressive pulmonary tuberculosis. After 2 and 4 months, plasmapheresis was found to arrest the intoxication syndrome in 56 and 100% of the patients, respectively. This treatment in these patients resulted in ceased bacterial isolation in 52% of the patients following 2 months and lung cavern closure in 36% of cases after 6 months.

mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p.

Cdc7p is a protein kinase that is required for G1/S transition and initiation of DNA replication in Saccharomyces cerevisiae. The mechanisms whereby Cdc7p and its substrates exerts their effects are unknown. We report here the characterization in S.