Publications by authors named "O P Akinwale"
In classical cerebellar learning, Purkinje cells (PkCs) associate climbing fiber (CF) error signals with predictive granule cells (GrCs) that were active just prior (∼150 ms). The cerebellum also contributes to behaviors characterized by longer timescales. To investigate how GrC-CF-PkC circuits might learn seconds-long predictions, we imaged simultaneous GrC-CF activity over days of forelimb operant conditioning for delayed water reward.
View Article and Find Full Text PDFHealth workers' perspectives on school-based mass drug administration control programs for soil-transmitted helminthiasis and schistosomiasis in Ogun State, Nigeria.
PLoS One
May 2024
Background: Soil-transmitted helminthiasis (STH) and schistosomiasis (SCH) are among the most prevalent neglected tropical diseases (NTDs), affecting 1.5 billion globally, with a significant burden in sub-Saharan Africa, particularly Nigeria. These diseases impair health and contribute to socio-economic challenges, especially in children, undermining educational and future economic prospects.
View Article and Find Full Text PDFHealth research mentorship in low-income and middle-income countries: a global qualitative evidence synthesis of data from a crowdsourcing open call and scoping review.
BMJ Glob Health
January 2024
Article Synopsis
- Research mentorship is crucial for advancing science, especially in low and middle-income countries (LMICs), but effective strategies for cultivating it are limited.
- A global qualitative synthesis, commissioned by WHO/TDR, incorporated data from an open call and a scoping review to identify practical strategies for enhancing mentorship in health research.
- Key strategies identified include recognizing mentorship as a team responsibility, leveraging existing resources, using digital tools for mentorship matching, promoting a culture of mentorship, and encouraging peer mentorship among researchers at similar career stages.
Background: Functional ultrasound imaging (fUS) is an emerging imaging technique that indirectly measures neural activity via changes in blood volume. Chronic fUS imaging during cognitive tasks in freely moving animals faces multiple exceptional challenges: performing large durable craniotomies with chronic implants, designing behavioral experiments matching the hemodynamic timescale, stabilizing the ultrasound probe during freely moving behavior, accurately assessing motion artifacts, and validating that the animal can perform cognitive tasks while tethered.
New Method: We provide validated solutions for those technical challenges.
Article Synopsis
- * Research involved qualitative methods like focus group discussions and in-depth interviews, identifying barriers to program uptake, including parental influence, lack of awareness, and concerns over side effects, while suggesting improvements in community engagement and collaboration.
- * Participants displayed some understanding of disease transmission but had misconceptions about causes and drug safety, indicating a need for enhanced health education and visibility of medical personnel to improve program effectiveness and public health outcomes.