Radiofrequency electromagnetic field ınhibits HIF-1 alpha and activates eNOS signaling to prevent intestinal damage in a model of mesenteric artery ischemia in rats.

Pathologies such as mesenteric artery ischemia and reperfusion (MIR) can lead to many organ dysfunctions, including the brain and heart through damage mechanisms induced in response to hypoxic conditions. Radiofrequency electromagnetic field (RF-EMF) can increase the vascularization of tissues by providing endothelial nitric oxide synthase (eNOS)-mediated nitric oxide (NO) release from the endothelium. The aim of this study is to investigate the protective effect and mechanism of RF-EMF in ischemic intestinal injury in the experimental MIR model.

Profiling of milk miRNAs associated with the innate immune system and pathway analysis in dairy cows with -infected subclinical mastitis.

We address the hypothesis that bioinformatics analysis can effectively identify miRNAs and target genes associated with the innate immune response to -induced mastitis in cows. Gram-positive bacteria, such as , are some of the mastitis pathogens that cause subclinical infection and pose one of the most severe threats to dairy cattle due to their contagiousness and incidence. Therefore, newer molecular markers must be identified to predict bovine mastitis non-invasively with low error and high specificity.

Anomaly Detection in Electronic Health Records Across Hospital Networks: Integrating Machine Learning With Graph Algorithms.

In a large hospital system, a network of hospitals relies on electronic health records (EHRs) to make informed decisions regarding their patients in various clinical domains. Consequently, the dependability of the health information technology (HIT) systems responsible for collecting EHR data is of utmost importance for patient safety. Recently novel methods and tools aimed at identifying anomalies in EHR data to bolster the reliability of HIT systems have been introduced.

Nebivolol attenuates acute systemic inflammation induced testicular dysfunction by decreasing transendothelial migration via VCAM-1/MMP-9 signaling.

Nebivolol (NB), which is a commonly used β adrenoreceptor blocker, shows protective effects against oxidative stress and inflammation-related processes. In this study, we aimed to evaluate the possible protective effects of NB via the vascular cell adhesion molecule-1/matrix metalloproteinases-9 (VCAM-1/MMP-9) signaling pathway on systemic inflammation induced testicular dysfunction. Four groups of 32 male Wistar Albino rats were divided as (n = 8 for each) the control; lipopolysaccharide (LPS; 5 mg/kg on the third day); LPS + NB (NB: 10 mg/kg for three days and 5 mg/kg LPS 30 min following the last NB dose); NB (10 mg/kg for three days).

Radiofrequency Electromagnetic and Pulsed Magnetic Fields Protected the Kidney Against Lipopolysaccharide-Induced Acute Systemic Inflammation, Oxidative Stress, and Apoptosis by Regulating the IL-6/HIF1α/eNOS and Bcl2/Bax/Cas-9 Pathways.

: Sepsis-associated acute kidney injury caused by lipopolysaccharide (LPS) is related to hypoxia, amplification of the inflammatory response, oxidative stress, mitochondrial dysfunction, and apoptosis. This study aims to explore the protective effects of a radiofrequency electromagnetic field (RF-EMF) and a pulsed magnetic field (PMF) on acute kidney injury in rats. : Forty female Wistar albino rats were randomly divided into five groups (each containing eight rats): control, LPS, RF-EMF, PMF, and RF-EMF + PMF groups.