Publications by authors named "O Ozkul-Wermester"
Article Synopsis
- The study investigates the differences between cerebral amyloid angiopathy-related inflammation (CAA-RI) and biopsy-positive primary angiitis of the CNS (BP-PACNS), focusing on their clinical and radiologic presentations as well as relapse rates.
- It included 104 patients with CAA-RI and 52 with BP-PACNS, revealing that CAA-RI tends to show more white matter lesions and hemorrhagic features, while BP-PACNS is associated more with headaches and motor deficits.
- The results indicate significant differences in features between the two conditions, suggesting that they may require different diagnostic approaches and could have varying outcomes in terms of recurrence.
Background: The use of thrombectomy in patients with acute stroke and a large infarct of unrestricted size has not been well studied.
Methods: We assigned, in a 1:1 ratio, patients with proximal cerebral vessel occlusion in the anterior circulation and a large infarct (as defined by an Alberta Stroke Program Early Computed Tomographic Score of ≤5; values range from 0 to 10) detected on magnetic resonance imaging or computed tomography within 6.5 hours after symptom onset to undergo endovascular thrombectomy and receive medical care (thrombectomy group) or to receive medical care alone (control group).
Background: The Alberta Stroke Program Early CT scan Score (ASPECTS) is a reliable imaging biomarker of infarct extent on admission but the value of 24-hour ASPECTS evolution in day-to-day practice is not well studied, especially after successful reperfusion. We aimed to assess the association between ASPECTS evolution after successful reperfusion with functional and safety outcomes, as well as to identify the predictors of ASPECTS evolution.
Methods: We used data from an ongoing prospective multicenter registry.
Impact of previous statin use on first intracerebral hemorrhage in cerebral amyloid angiopathy.
Rev Neurol (Paris)
December 2023
Objectives: Statins have been associated with an increased risk of spontaneous intracerebral hemorrhage (ICH), but without dedicated study in cerebral amyloid angiopathy (CAA). We aimed to evaluate the association between previous statin treatment and radiological hemorrhagic lesions in a CAA population during a first lobar ICH event.
Materials And Methods: We retrospectively included all patients meeting the modified Boston criteria for probable CAA and admitted for a first lobar ICH between 2010 and 2021 at Rouen University Hospital.
Article Synopsis
- The study aimed to validate the Edinburgh diagnostic criteria for identifying cerebral amyloid angiopathy (CAA) in patients with non-traumatic intracerebral lobar hemorrhage (ICH) using CT and MRI scans, excluding genetic factors like APOE status.
- Researchers included 102 patients and found that 36 had CAA, while 46 had non-CAA causes, and they achieved an AUC of 0.760 for the original Edinburgh model, which improved to 0.808 with the addition of cortical involvement as a feature.
- The conclusion supports the use of modified Boston MRI criteria for diagnosing CAA and proposes a new three-variable prediction model to enhance diagnostic accuracy in urgent cases of spontaneous lobar ICH.