Background: In the UK, few (12%) anal squamous cell carcinomas (aSCC) are diagnosed early at stage 1 (T1N0M0). The Homerton Anogenital Neoplasia Service (HANS) is a highly specialised tertiary centre where high resolution anoscopy (HRA) is performed to diagnose and treat anal intraepithelial neoplasia (AIN), a precursor to cancer. In some cases, aSCC (here defined as anal canal cancers and perianal cancers up to 5cm from the anal verge) is found on referral for AIN; in others, aSCC may develop while undergoing AIN management.
View Article and Find Full Text PDFBackground: Bivalent SARS-CoV-2 vaccines were developed to counter increasing susceptibility to emerging SARS-CoV-2 variants. We evaluated the durability of immunity and protection following first bivalent vaccination among nursing home residents.
Methods: We evaluated anti-spike and neutralization titers from blood in 653 community nursing home residents before and after each monovalent booster, and a bivalent vaccine.
Background: In Nigeria, 97% of the population is at risk of contracting malaria. It is transmitted by female mosquitoes carrying the parasite and can be lethal. An estimated 55 million illnesses and 80,000 deaths per year result from it.
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