The Impact of Diabetes Self-Management Education (DSME) on the Quality of Life of patients living with type-2 Diabetes Mellitus in Nigeria.

Background: Type 2 diabetes mellitus (T2DM) significantly affects the quality of life (QoL), necessitating comprehensive management strategies. In resource-limited settings such as Nigeria, managing diabetes can be challenging due to limited access to medications, which impacts patients' QoL. Diabetes Self-Management Education (DSME) empowers patients through knowledge and skills, potentially improving their QoL.

Validation and pharmacokinetic application of a high-performance liquid chromatographic technique for determining the concentrations of amodiaquine and its metabolite in plasma of patients treated with oral fixed-dose amodiaquine-artesunate combination in areas of malaria endemicity.

Artemisinin-based combination therapies (ACTs) have been adopted by most African countries, including Nigeria, as first-line treatments for uncomplicated falciparum malaria. Fixed-dose combinations of these ACTs, amodiaquine-artesunate (FDC AQAS) and artemether-lumefantrine (AL), were introduced in Nigeria to improve compliance and achieve positive outcomes of malaria treatment. In order to achieve clinical success with AQAS, we developed and validated a simple and sensitive high-performance liquid chromatography (HPLC) method with UV detection for determination of amodiaquine (AQ) and desethylamodiaquine (DAQ) in plasma using liquid-liquid extraction of the drugs with diethyl ether following protein precipitation with acetonitrile.

Resolution pattern of jaundice among children presenting with severe malaria in rural South-West Nigeria.

Objective: To compare the pattern of jaundice resolution among children with severe malaria treated with quinine and artemether.

Methods: Thirty two children who fulfilled the inclusion criteria were recruited for the study from two hospitals with intensive care facilities. They were divided into two groups; 'Q' and 'A', receiving quinine and artemether, respectively.

Effect of artemether on hematological parameters of healthy and uninfected adult Wistar rats.

Objective: To evaluate the effect of short term artemether administration on some blood parameters in adult male Wistar rats.

Methods: Sixty five albino rats with body weight of 190-220 g were used for the four-phased study. The animals were randomly divided into five groups.

Brand variations in the physicochemical properties of metronidazole tablets.

This study investigated possible variations in the physiochemical properties of seven brands of metronidazole tablets obtained from different retail pharmacy outlets in Nigeria. The different brands were subjected to various tests such as uniformity of weight, crushing strength, friability, disintegration and dissolution. Chemical assays were also carried out on the tablets.