Vaccine development for bacterial pathogens: Advances, challenges and prospects.

The advent and use of antimicrobials have played a key role in treating potentially life-threatening infectious diseases, improving health, and saving the lives of millions of people worldwide. However, the emergence of multidrug resistant (MDR) pathogens has been a significant health challenge that has compromised the ability to prevent and treat a wide range of infectious diseases that were once treatable. Vaccines offer potential as a promising alternative to fight against antimicrobial resistance (AMR) infectious diseases.

The Emotional and Personal Experiences of the COVID-19 Illness During the Early Pandemic: A Qualitative Study.

Background: Several studies report the incidence of psychiatric symptoms and disorders among patients who recovered from coronavirus disease 2019 (COVID-19); however, little is known about the emotional impact of acute COVID-19 illness and recovery on these survivors. Qualitative methods are ideal for understanding the psychological impact of a novel illness.

Objective: To describe the emotional experience of the acute COVID-19 illness and recovery in patients who contracted the virus during the early months of the pandemic.

Evaluation of aquifer hydraulic conductivity and transmissivity of Ezza/Ikwo area, Southeastern Nigeria, using pumping test and surficial resistivity techniques.

Aquifer hydraulic parameters including hydraulic conductivity and transmissivity play a very important role in the assessment and management of groundwater. Conventionally, these parameters are best estimated employing pump test, which is usually expensive and time-consuming. The use of surficial electrical resistivity data integrated with few available pumping test data provides a cost-effective and efficient alternative.

The resurgence of phage-based therapy in the era of increasing antibiotic resistance: From research progress to challenges and prospects.

Phage therapy was implemented almost a century ago but was subsequently abandoned when antibiotics emerged. However, the rapid emergence of drug-resistant, which has brought to the limelight situation reminiscent of the pre-antibiotic era, coupled with the unavailability of new drugs, has triggered the quest for an alternative therapeutic approach, and this has led to the rebirth of phage-derived therapy. Phages are viruses that infect and replicate in bacterial cells.

A Longitudinal Study of COVID-19 Sequelae and Immunity: Baseline Findings.

Background: A substantial proportion of persons who develop COVID-19 report persistent symptoms after acute illness. Various pathophysiologic mechanisms have been implicated in the pathogenesis of postacute sequelae of SARS-CoV-2 infection (PASC).

Objective: To characterize medical sequelae and persistent symptoms after recovery from COVID-19 in a cohort of disease survivors and controls.