Publications by authors named "O Oguz Demir"
The N-Myc transcription factor, encoded by MYCN, is a mechanistically validated, yet challenging, target for neuroblastoma (NB) therapy development. In normal neuronal progenitors, N-Myc undergoes rapid degradation, while, in MYCN-amplified NB cells, Aurora kinase A (Aurora-A) binds to and stabilizes N-Myc, resulting in elevated protein levels. Here, we demonstrate that targeted protein degradation of Aurora-A decreases N-Myc levels.
View Article and Find Full Text PDFBackground: Immune checkpoint inhibitors (ICI) are generally associated with rare cardiac side effects, yet instances like myocarditis can be fatal. Therefore, detecting and managing left ventricular dysfunction early in ICI therapy is vital.
Objectives: This study aims to evaluate whether left ventricular global longitudinal strain (LV GLS) is a predictor for early detection of cardiac dysfunction in patients receving ICI.
Introduction: Transcatheter aortic valve replacement (TAVR) is increasingly in demand for treating severe aortic stenosis in a variety of surgical risk profiles. This means increasing wait times and elevated morbidity and mortality on the waitlist. To address this, we developed the SWIFT TAVR algorithm to prioritize patients based on clinical risk and reduce wait times.
View Article and Find Full Text PDFArticle Synopsis
- The study examines the superficial palmar branch of the radial artery (SUPBRA) to improve techniques for reconstructing palmar skin, focusing on its anatomy and harvesting methods.
- Researchers dissected 19 male hand specimens to gather detailed anatomical data, including dimensions and positions of key structures related to SUPBRA, analyzing how best to utilize this flap in reconstruction efforts.
- Results indicated that the SUPBRA has adequate dimensions for viability in surgical applications, with specific measurements and the identification of critical vascular contributions that ensure successful use in cases of hand injury.