Publications by authors named "O O Piven"
Pyridoxal-5-phosphate (PLP) enhances the synthesis of endogenous hydrogen sulfide, a potent regulator of cell metabolism. We used 24-month-old rats to investigate the PLP mitoprotective function in the aging heart. We demonstrated improvement of mitochondrial bioenergetic functions, inhibition of mPTP opening after PLP administration.
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- The study examines the biocompatibility and osteoinductive properties of bioactive ceramics made from single-phase hydroxyapatite (HAP) and two-phase HAP with β-TCP, focusing on various chemical modifications.
- The results show that treatments improved the ceramics' solubility, increased porosity, and enhanced adsorption activity, leading to favorable conditions for cell adhesion and survival in culture.
- Calcium phosphate ceramics were found to stimulate important cellular processes, suggesting these HAP-based bioceramics could be effective for bone regeneration and reconstruction.
We have asked Ukrainian scientists how they have been able to persist in pursuing their research since the beginning of the full-scale invasion of Ukraine by the Russian Federation in February of 2022. We thank the scientists who were willing to share their thoughts and experiences; the views expressed are those of the contributors alone.
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- The study examines how aging affects protective mechanisms in the body, particularly focusing on ATP-sensitive potassium channels and their role in heart protection via pyridoxal-5-phosphate (PLP) treatment.
- Experiments were conducted on adult and aged rats to assess the impact of PLP on heart health, including mRNA and protein expressions of potassium channels, heart tissue morphology, and responses in cardiac function during stress tests.
- Results indicated that PLP treatment in older rats reduced heart fibrosis, improved heart function under stress, and increased the expression of specific potassium channel subunits while also reducing oxidative stress markers, suggesting a potential therapeutic benefit of PLP through enhanced potassium channel activity and production of protective substances.
The WNT/β-catenin pathway is a master regulator of cardiac development and growth, and its activity is low in healthy adult hearts. However, even this low activity is essential for maintaining normal heart function. Acute activation of the WNT/β-catenin signaling cascade is considered to be cardioprotective after infarction through the upregulation of prosurvival genes and reprogramming of metabolism.
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