Publications by authors named "O O Opaleye"
Article Synopsis
- This study examined the genomic characteristics and transmission dynamics of SARS-CoV-2 in Nigeria during its first and second outbreaks.
- Researchers used whole genome sequencing to identify different variants and analyzed their phylogenetic relationships.
- Four main variants were found, with Alpha being the most common, indicating the possibility of multiple virus introductions and potential for more aggressive variants to emerge.
Introduction: (Hepatitis E virus; HEV) is an emerging virus that poses as a public health threat. The virus is now reported to be the leading cause of acute viral hepatitis, with a unique impact on African settings. Our aim was to evaluate the prevalence and risk factors for HEV infection in three cohorts (animal handlers, villagers, and students).
View Article and Find Full Text PDFBackground: Hepatitis C virus (HCV) a major human pathogen infecting millions of individuals worldwide, thereby increasing the risks for chronic liver diseases and has been discovered that HIV/HCV co-infected patients have a greater risk.
Objective: To determine the prevalence of HCV infection among HIV infected people in Port Harcourt, Rivers State.
Methodology: The patients were from the ages of 18 and above attending the antiretroviral clinic for over 6 months.
Our study aim was to describe and characterize the global Hepatitis E virus (HEV) molecular and genotype geographical distribution in domestic pig and wild boar, which could facilitate the traceability of human cases. We performed a systematic sequence search for HEVs identified in domestic pig and wild boar from the available data in GenBank. Only sequences with lengths greater than 300 nt were included.
View Article and Find Full Text PDFAs the global effort to eradicate hepatitis B continues, immune escape mutations (IEMs) and drug resistance mutations (DRMs) affecting its diagnosis, treatment, and prevention are compromising this goal. However, knowledge about the prevalence and circulation of these mutations in Nigeria is scarce. Serum samples ( = 199) from apparently healthy prospective blood donors, pregnant women, and individuals presenting with fever in southwestern Nigeria were analyzed for the presence of IEMs and DRMs by means of nested PCR in the HBV S (HBs) and HBV polymerase (Pol) genes, followed by phylogenetic and mutational analyses.
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