Publications by authors named "O O Odubela"
Hydroxyurea (HU) is a disease-modifying therapy with significant clinical and laboratory efficacy among individuals living with sickle cell anaemia (SCA). This is evident through increased fetal haemoglobin, higher packed cell volume, improved red cell hydration, reduced leukocytes, and platelet function. The effect on the coagulation pathway and pathophysiologic mechanism remains unclear, especially in children living with SCA.
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- * The research involved 250 children-125 experiencing VOC and 125 healthy controls, with MI prevalence rates of 42.4% and 23.2% based on troponin T, and 40.8% and 20.8% via ECG, respectively.
- * Key risk factors for MI included older age, pain severity, length of illness, and high white blood cell and platelet counts, with age, pain intensity, and platelet levels
Background: Evidence-based research remains the cornerstone in changing the narrative of wholesome health among Adolescents and Young Adults Living with HIV (AYALHIV). However, little is known about the perceptions of AYALHIV in research participation and outcomes, in low- and middle-income countries, especially in sub-Saharan Africa. This study describes the perception of AYALHIV in research participation and outcome in Lagos, Nigeria.
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- * Data from 2,772 ART-naïve adults were analyzed, revealing a CKD prevalence of 10.0% to 17.6%; the study found that older age and factors such as anemia, lower BMI, and low CD4 counts were significantly associated with CKD.
- * Three methods for estimating CKD (BSA-CG, MDRD, and CKD-EPI) were compared, with
Background: Acute diarrhoea is a significant cause of morbidity and mortality in children under five, especially in subSaharan Africa. The WHO recommends using oral rehydration solution (ORS) and zinc therapy for its management, but the metallic taste of zinc often hinders adherence.
Method: This prospective open-label intervention study took place at three health facilities in Lagos, Southwest Nigeria, involving children aged 3 to 59 months with acute diarrhoea.