Publications by authors named "O O Melkadze"

Unlabelled: The inclusion of 7-10-year-old children in the school system occurs in the context of the interaction of two processes: activation of ontogenesis at this stage of age development and stimulation of biological and psychological adaptation of younger schoolchildren to the learning activity. The main factors negatively affecting the health of elementary school students are the following: hypokinesia, mental and psycho-emotional stress related to computer and digital learning technologies, prolonged stay in closed rooms of the educational institution rather than in the natural environment. In this regard, it is relevant to find ways to improve the adaptive capacity of children, their physical development (PD), musculoskeletal system (MS), and muscular core as a biological basis for learning activities.

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The aim of the work is study of adsorbtion dynamics of amitriptiline on the surface of erythrocytes and to compare the obtained data with the character of pharmacokinetics and pharmacodynamics of amitriptiline in plasma. With the method of PLC the adsorb gas was been analyzed. The drag was administered to adult drugs and the blood sampled were collected following 10, 20, 60 min.

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The pharmacokinetics and pharmacodynamics of Trazodone were investigated by HPLC chromatography in the blood plasma and in the erythrocyte supernatant. Two groups of samples (plasma and supernatant) were monitored. The drug was administered to adult dogs and the blood samples were collected for further analysis following 10, 20, 60 min.

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