Impact of risk factors of ischemic heart disease on the development of acute coronary syndrome, platelet ultrastructure, and aspirin resistance.

Objective: Introduction: Risk factors of ischemic heart disease have an impact on blood cell apoptosis, platelets in particular, and their calcification. 5-40% of patients with high cardiovascular risk have anti-platelet drug resistance. The study of the morphofunctional status of platelets in patients with acute coronary syndrome is relevant and requires further research.

[Structural and dynamical properties of apical and mitochondrial membranes of enterocytes in experimental enteric pathology and the method of its correction].

Structural and dynamical state of the apical and mitochondrial membranes of enterocytes of the rat small intestine under experimental enteric pathology conditions have been investigated. The modifications of structural and dynamical features of membranes at the use of BAA FLP-MD have been shown. The similarities arising in the versatile destructive changes of membranes are as follows: modification of the lipid phase structure of the membrane, changes in dynamical properties of membrane components and topography, disorders of hydrophobic protein-lipid interactions, conformational changes of protein molecules etc.