Publications by authors named "O O Kirilochev"
Objective: Access to literature on clozapine in Russian language remains strikingly limited. We aimed to identify and translate clinical evidence on clozapine-based treatment outcomes.
Methods: We performed a systematic review in PubMed, Embase and scientific indexes from former USSR states searching for articles published in Russian from the database inception till January 2023 and summarized the data in a scoping review (PROSPERO Reg.
Article Synopsis
- A recent article discussed the modernization of clozapine prescriptions in the US, addressing concerns about agranulocytosis—a serious side effect of this medication.
- In contrast, an international group examined the global outcomes of clozapine use, highlighting that adverse reactions to the drug may vary across different countries.
- Research indicated that while some countries like Finland and Denmark reported no increased mortality linked to clozapine, the UK showed a worrying trend of rising fatal outcomes associated with the drug, particularly due to conditions like pneumonia and myocarditis rather than agranulocytosis.
Clozapine-induced myocarditis in Russia: Animal studies but no clinical studies.
Rev Psiquiatr Salud Ment (Engl Ed)
December 2022
White blood cell (WBC) monitoring has reduced clozapine-treated patient deaths associated with agranulocytosis to a rarity. However, clozapine protocols and package inserts worldwide provide no instructions for preventing myocarditis or pneumonia during clozapine titrations. Prescribers worldwide are largely unaware of that.
View Article and Find Full Text PDF