Effects of ouabain on potassium transport and cell volume regulation in rat and rabbit liver.

1. We have examined whether the apparently ouabain-resistant fraction of cellular volume regulation in liver slices under isosmotic conditions is due to a failure of ouabain to cause complete inhibition of the coupled transport of Na+ and K+. The ion and water contents of rat and rabbit liver slices were altered by pre-incubation at 1 degree C and then allowed to recover at 38 degrees C, with or without ouabain or other inhibitors.