Investigation of Inter- and Intra-Day Variability of Tear Fluid Regarding Flow Rate, Protein Concentration as well as Protein Composition.

Purpose: The purpose of this study was to present the determination of inter- and intra-day variations in tear flow rate, and tear fluid protein concentration, as well as protein composition regarding their impact for future biomarker studies.

Methods: Tear fluid was collected noninvasively from 18 healthy subjects by performing Schirmer tests at 4 different time points repetitive in a period of 2 days. The tear flow rate on the Schirmer test strips was measured.

Meningeal T cells function in the central nervous system homeostasis and neurodegenerative diseases.

Recently, a rising interest is given to neuroimmune communication in physiological and neuropathological conditions. Meningeal immunity is a complex immune environment housing different types of immune cells. Here, we focus on meningeal T cells, possibly the most explored aspect of neuro-immune cell interactions.

Data related to influence of process parameters on the microstructure, structural and mechanical properties of additive manufactured titanium alloy composites.

Instead of tampering with the whole microstructure of titanium alloy base structure, direct laser metal deposition (DLMD) method can be used to target and solve a particular problem. This will result in extended application of titanium alloy. The enhancement of titanium alloy service life span can be done by fabricating composite coatings on titanium alloy.

IoMT: A COVID-19 Healthcare System Driven by Federated Learning and Blockchain.

Internet of medical things (IoMT) has made it possible to collect applications and medical devices to improve healthcare information technology. Since the advent of the pandemic of coronavirus (COVID-19) in 2019, public health information has become more sensitive than ever. Moreover, different news items incorporated have resulted in differing public perceptions of COVID-19, especially on the social media platform and infrastructure.

Complement cascade functions during brain development and neurodegeneration.

The complement system, an essential tightly regulated innate immune system, is a key regulator of normal central nervous system (CNS) development and function. However, aberrant complement component expression and activation in the brain may culminate into marked neuroinflammatory response, neurodegenerative processes and cognitive impairment. Over the years, complement-mediated neuroinflammatory responses and complement-driven neurodegeneration have been increasingly implicated in the pathogenesis of a wide spectrum of CNS disorders.