Nafamostat in hospitalized patients with moderate to severe COVID-19 pneumonia: a randomised Phase II clinical trial.

Background: Nafamostat, a serine protease inhibitor, has been used for the treatment of disseminated intravascular coagulation and pancreatitis. In vitro studies and clinical reports suggest its beneficial effect in the treatment of COVID-19 pneumonia.

Methods: This phase 2 open-label, randomised, multicentre, controlled trial evaluated nafamostat (4.

Extracellular Synthesis of Luminescent CdS Quantum Dots Using Plant Cell Culture.

The present study describes a novel method for preparation of water-soluble CdS quantum dots, using bright yellow-2 (BY-2) cell suspension culture. Acting as a stabilizing and capping agent, the suspension cell culture mediates the formation of CdS nanoparticles. These semiconductor nanoparticles were determined by means of an UV-visible spectrophotometer, photoluminescence, high-resolution transmission electron microscopy (HRTEM), and XRD.

[PLANT GENETIC TRANSFORMATION USING CARBON NANOTUBES FOR DNA DELIVERY].

The possibility of exploiting carbon nanotubes (CNTs)-based nanocarriers to deliver genes into protoplasts, callus and mesophyll explants of plants was examined. Using single-walled CNTs (SWCNTs) at the concentration of 20 μg/ml and multi-walled CNTs (MWCNTs) at the concentration of 15 μg/ml genetic transformation of Nicotiana tabacum L. mesophyll protoplasts with plasmid pGreen 0029 was carried out and transient expression of reporter yfp gene in the protoplasts was observed.

[Results of monopolar versus quasibipolar transurethral resection of the prostate and urinary bladder].

We compared efficacy and safety of mono- vs quasibipolar transurethral resection (TUR) for 198 patients treated with TUR. The patients were randomized into two groups by the TUR variant: mono-or quasibipolar. Comparison ofpre- and postoperative examinations data in the above two groups demonstrated: blood sodium decreased more in patients from monopolar TUR group, the absence of TUR-syndrome and less frequent and severe symptoms of obturator nerve irritation after quasibipolar TUR.

[Unintended effects of genetic modifications in plants and methods of their analysis].

The problem of unintended effects caused by genetic modification of plants is analysed. Factors that can provoke the unintended effects in genetically engineered plants, their consequences and possibility of the avoiding of unintended effects with use of current methods of genetic modification are discussed. Modern methodological approaches applied to analyse the unintended effects during the safety assessment of transgenic plants, in particular methods of molecular profiling with different "-omic"-technologies are described.