Anthelmintic activity of three selected ethnobotanical plant extracts against Strongyloides venezuelensis.

The agropastoral farmers have employed Turraea vogelii(TVL),Senna podocarpa(SPL), and Jaundea pinnata (JPL) leaves for treating various diseases, including intestinal parasites in livestock and the human population in Nigeria. Gastrointestinal nematodes are highly significant to livestock production and people's health, and natural products are interesting as sources of new drugs. In this study, we evaluated the effectiveness of extracts derived from these plants in treating parasitic infections using third-stage infective larvae (L3) of Strongyloides venezuelensis.

Dabsylated Bradykinin Is Cleaved by Snake Venom Proteases from .

The vasoactive peptide bradykinin (BK) is an important member of the renin-angiotensin system. Its discovery is tightly interwoven with snake venom research, because it was first detected in plasma following the addition of viper venom. While the fact that venoms liberate BK from a serum globulin fraction is well described, its destruction by the venom has largely gone unnoticed.

Chemical Constituents from Stem Bark and Their Antimicrobial Activities.

The phytochemical investigation of the ethylacetate fraction of an ethanolic extract obtained from the stem bark of (Moraceae) led to the isolation of four flavonoids: (2)-eriodictyol (), 2'- hydroxygenistein (), erycibenin A (), and genistein (); a dihydrobenzofuran: moracin P (); a coumarin: peucedanol (); and an apocarotenoid terpenoid: dihydrophaseic acid (). These were identified via 1D and 2D nuclear magnetic resonance spectroscopy (NMR) and ultra-high-resolution liquid chromatography-quadrupole time-of-flight mass spectroscopy (UHPLC-QTOF MS). Moracin P () is being reported for the first time in the genus while the others are known compounds ( and ) isolated previously from the genus but being reported for the first time from the species .

Phytochemical screening and in vitro anthelmintic activity of methanolic extract of Terminalia glaucescens leaf on Haemonchus contortus eggs.

Helminth infections remain a major constraint to livestock productivity in the tropical and subtropical areas across the world, especially in the areas where extensive grazing is practiced. The development of resistance to anthelmintic drugs, scarcity and high cost of purchase especially to farmers of low income in developing countries led to the need of alternative helminth control methods. However, there is an urgent need to discover novel drugs that can cure helminthiasis.

Gakolanone: a new benzophenone derivative from Heckel stem-bark.

Gakolanone (3',5'-digeranyl-2',4',6',3-tetrahydroxybenzophenone; ), a novel benzophenone derivative was isolated from the hexane extract of Heckel stem-bark along with three known 3-8'' linked biflavonoids: 3'',4',4''',5,5'',7,7''-heptahydroxy-3,8''-biflavanone (); 3'',4',5,5'',5''',7,7''-heptahydroxy-4-methoxy-3,8''-biflavanone () and 4',4''',5,5'',7,7''-hexahydroxy-3,8''-biflavanone () from the ethanol extract. The compounds were characterized primarily using 1 D and 2 D nuclear magnetic resonance spectroscopy and mass spectrometry and by comparing with literature. The compounds were subjected to alpha-amylase enzyme inhibitory assay using DNSA (3,5-dinitrosalicylic acid) reagent with acarbose used as the standard drug.