The Human Milk Oligosaccharide Lacto-N-Fucopentaose III Conjugated to Dextran Inhibits HIV Replication in Primary Human Macrophages.

: Individuals with HIV on combined antiretroviral therapy (ART) with virologic suppression exhibit chronic immune activation and immune dysfunction. Numerous studies have shown that human milk oligosaccharide (HMO) controls the postnatal transmission of HIV-1, but its effect on adult HIV-1 infection is not known. The purpose of this study was to investigate the anti-HIV activity of Lacto-N-fucopentaose III (LNFPIII) in adult blood-borne macrophages.

Biodegradable and antibacterial edible films based on egg yolk granules/gelatin/CMC with e-poly-l-lysine: Application in fresh chicken meat preservation.

Novel biodegradable and antibacterial edible films were fabricated by incorporating E-poly-l-lysine (EPL) into egg yolk granules, gelatin, and sodium carboxymethyl cellulose matrices. With increasing EPL concentration (0.3-0.

Recent Occurrence and Rapid Spread of Multidrug-Resistant Infantis in Broiler Flocks in Korea.

Infantis has recently been one of the most prevalent serotypes in poultry and has been identified in human salmonellosis cases worldwide. Multidrug-resistant (MDR) Infantis has emerged as a significant threat to both poultry production and public health due to its increasing prevalence and global dissemination. We identified the occurrence of an MDR Infantis clone in broiler flocks in Korea, and the clone was characterized to explore potential genetic causes for its high prevalence and rapid spread in broiler production.

Persistently Active Infection Is Associated with the Development of Metabolic Dysfunction-Associated Steatotic Liver Disease.

Previous studies suggested a link between ( infection and steatotic liver disease, now termed metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to identify the association of active infection and the new concept of MASLD in a longitudinal cohort. We reviewed 1497 health examinees who had two endoscopic biopsies for activity without hepatic steatosis at the baseline abdominal ultrasonography.

Biosynthesis of biodegradable plastic, poly(3HB-co-3HP), using methane as sole carbon source in metabolically engineered type II methanotroph, Methylosinus trichosporium OB3b.

We report a biosynthetic method for producing poly(3-hydroxybutyrate-co-3-hydroxypropionate) [P(3HB-co-3HP)] copolymer from methane alone; we developed a 3-hydroxypropionate (3HP) biosynthetic pathway starting from methane in Methylosinus trichosporium OB3b and overexpressed 3HP-CoA transferase to optimize 3HP incorporation into P(3HB-co-3HP) copolymers. Upon comparing the β-alanine and malonyl-CoA pathways, we discovered that the latter showed greater potential for the formation of 3HP monomers. In addition, we examined the activities of 3HP-CoA synthetases from three distinct sources and found that the enzyme from Metallosphaera sedula was the most effective for 3HP incorporation.