Publications by authors named "O Nakano"
Increase in muscle mass associated with the prebiotic effects of 1-kestose in super-elderly patients with sarcopenia.
Biosci Microbiota Food Health
February 2021
Article Synopsis
- - The study explores how prebiotics, specifically 1-kestose, impact the intestinal microbiota and muscle health in elderly patients suffering from sarcopenia, a condition leading to reduced muscle mass and functionality.
- - Results showed that after 12 weeks of 1-kestose administration, there was a significant increase in beneficial gut bacteria and improvements in body composition, including a higher skeletal muscle mass index and lower body fat percentage in the patients.
- - This research is notable as it is the first to demonstrate that prebiotic supplementation can positively alter gut microbiota composition and support recovery from muscle atrophy in very elderly individuals with sarcopenia.
Background: Involuntary weight loss related to cachexia is common in patients with advanced cancer, but the association between body composition changes and survival is still unclear in pancreatic cancer.
Methods: We retrospectively reviewed the clinical outcomes of 55 patients with advanced pancreatic cancer undergoing palliative therapy or best supportive care (BSC). The skeletal muscle index (SMI), visceral adipose tissue index (VATI), subcutaneous adipose tissue index (SATI), and visceral to subcutaneous adipose tissue area ratio (VSR) were calculated based on the cross-sectional area on two sets of computed tomography images obtained at cancer diagnosis and 1 month later before treatment.
Considering the increase in cases of non-alcoholic steatohepatitis (NASH), the use of appropriate animal model of NASH is essential to understand the underlying pathogenesis mechanism. To date, several mice models have been used; however, significant differences in the etiologies and food administered affected the results, with inconsistent conclusions. Therefore, it is necessary to understand these models and their differences to be able to choose appropriate models.
View Article and Find Full Text PDFBackground: Prognosis of patients with hepatocellular carcinoma (HCC) who undergo transcatheter intra-arterial therapies, including transcatheter arterial chemoembolization and transcatheter arterial infusion chemotherapy, is affected by many clinical factors including liver function and tumor progression. However, the effect of body composition such as skeletal muscle and visceral and subcutaneous adipose tissues (VAT and SAT, respectively) on the prognosis of these patients remains unclear. We investigated the prognostic value of body composition in HCC patients treated with transcatheter intra-arterial therapies.
View Article and Find Full Text PDFBackground: The impact of sarcopenia on the prognosis of patients with hepatocellular carcinoma (HCC) who receive transcatheter intra-arterial therapies, including transcatheter arterial chemoembolization and transcatheter arterial infusion chemotherapy, remains unclear. We investigated the prognostic value of skeletal muscle loss (SML) stratified by cutoffs for sarcopenia and rate of change in skeletal muscle mass over 6 months.
Methods: We retrospectively evaluated 102 patients with HCC treated with transcatheter intra-arterial therapies between 2005 and 2015.