[Elevation of proinflammatory cytokines level at early age as the risk factor of neurological and mental pathology development].

Proinflammatory cytokines Interleukin-1, Interleukin-6 (IL-1, IL-6) and tumour necrosis factor alpha (TNFalpha), the key mediators of neuroimmune interactions, are the common pathogenic part of various kinds of the perinatal pathology leading to severe neurological and mental diseases. In the review, features of expression of the proinflammatory cytokines and their receptors in the brain at early age under normal and pathological conditions, their influence on processes of maturing of the CNS cells are described, the data of experimental and clinical researches of disturbances of the mental functions arising in adults owing to elevation of the IL-1, IL-6 levels and TNFalpha in early ontogenesis are cited. The role of the cytokines in pathogenesis of schizophrenia, a syndrome of attention deficiency, autism and a Parkinsonism is discussed.

[Periodontal function after replantation].

The components of periodontal connective tissue were studied on days 28-30 after replantation of the teeth with the extra-alveolar time 5, 15, and 30 min. The levels of collagen, glucosaminoglycanes, sialic acids, and activity of sialidase increased at extra-alveolar time 30 min by 44, 33, and 20, and 85%, respectively. Introduction of potassium hyaluronate in dental wells reduced the sail collagen growth in the periodontal tissue.

[Determination of free and bound forms of sialic acids in biologic objects].

A method for simultaneous measurements of free, oligomer-bound and protein-bound sialic acids in the blood serum, saliva, and tissue homogenates is offered. The results of these parameters measurements after stressogenic exposures and in some diseases are presented.

[The effect of vicasol and pelentan on the biopolymers of the periodontium].

Vitamin K (vikasol) and pelentan were examined for their effects of periodontal tissue levels of collagen, hexosamine-containing biopolymers and sialoglycoproteins. During tooth replantation in dogs, vitamin K was demonstrated to elevate the levels of collagen, hexosamine-containing polymers in periodontal tissue by 25.8, 19.

[Indices of hexosamine-containing biopolymers in experimental tooth replantation].

The experimental findings showed that the content of hexosamine-containing biopolymers, in periodontal tissue increased by 38.23 and 124% conformably over 14 days after replantation of 4 teeth of the dogs. The indices normalized in 28 days of the experiment.