[The quality of life of adolescents as integral characteristic of pre-nosologic health condition].

The purpose of the study is to establish characteristics of quality of life of adolescents and substantiate it as a reference criterion of pre-nosologic condition of health for mass screening observations of adolescent population. During puberty, in adolescents, mainly in girls, deterioration of quality of life is established. At that, minimal indices of quality of life were registered in adolescents 12 years old, that is probably conditioned by decreasing of level of functioning of central and respiratory systems against the background of vegetative balance disorders in this age group as compared with students of other age groups.

APOL1 genotype-associated morphologic changes among patients with focal segmental glomerulosclerosis.

Background: The G1 and G2 alleles of apolipoprotein L1 (APOL1) are common in the Black population and associated with increased risk of focal segmental glomerulosclerosis (FSGS). The molecular mechanisms linking APOL1 risk variants with FSGS are not clearly understood, and APOL1's natural absence in laboratory animals makes studying its pathobiology challenging.

Methods: In a cohort of 90 Black patients with either FSGS or minimal change disease (MCD) enrolled in the Nephrotic Syndrome Study Network (58% pediatric onset), we used kidney biopsy traits as an intermediate outcome to help illuminate tissue-based consequences of APOL1 risk variants and expression.

Genetic polymorphism under cyclical selection in long-lived species: The complex effect of age structure and maternal selection.

Maternal selection and overlapping generations can facilitate the stable coexistence of alleles under temporally fluctuating environment. Using mathematical models, we considered the complex effect of both factors on the maintenance of genetic polymorphism in cyclically changing environments. We concentrated on asymmetric cyclic selection, which allows describing fluctuations of environments by analogy of food resources cycles with rare peaks and prolonged decline of prey abundance.

Acute Peritoneal Dialysis During the COVID-19 Pandemic at Bellevue Hospital in New York City.

Background: The COVID-19 pandemic strained hospital resources in New York City, including those for providing dialysis. New York University Medical Center and affiliations, including New York City Health and Hospitals/Bellevue, developed a plan to offset the increased needs for KRT. We established acute peritoneal dialysis (PD) capability, as usual dialysis modalities were overwhelmed by COVID-19 AKI.

Colloid-SEM method for the investigation of magnetic domain structures.

The paper presents scanning electron microscopy (SEM) studies on the magnetic domain structure (DS) using magnetic colloid. The possibility of colloid-SEM method for observing the DS of mono- and polycrystalline samples in the secondary (SEI) and backscattered electrons modes (BEC) is demonstrated. Owing to the large focal depth of SEM, it is possible to observe the overall DS and fine features, even in unpollished samples.