Publications by authors named "O N Volkov"
Background/aim: The current systematic review aimed to collect and analyze all available published and unpublished cases in which prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (Lu-PSMA) was used to treat non-prostatic cancer.
Materials And Methods: Literature search and evidence acquisition through contacts with organizations that use Lu-PSMA were employed. PubMed/Medline, SCOPUS, and ScienceDirect searches were performed following PRISMA recommendations.
Additive nanotechnology enable curvilinear and three-dimensional (3D) magnetic architectures with tunable topology and functionalities surpassing their planar counterparts. Here, we experimentally reveal that 3D soft magnetic wireframe structures resemble compact manifolds and accommodate magnetic textures of high order vorticity determined by the Euler characteristic, χ. We demonstrate that self-standing magnetic tetrapods (homeomorphic to a sphere; χ = + 2) support six surface topological solitons, namely four vortices and two antivortices, with a total vorticity of + 2 equal to its Euler characteristic.
View Article and Find Full Text PDFG protein-coupled receptors (GPCRs) form the largest superfamily of membrane proteins in the human genome, and represent one of the most important classes of drug targets. Their structural studies facilitate rational drug discovery. However, atomic structures of only about 20% of human GPCRs have been solved to date.
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- The study focuses on the complex behavior of G-protein-coupled receptors (GPCRs) and how their shape changes impact their function in the body.
- Researchers used single-molecule Förster Resonance Energy Transfer (smFRET) to observe the conformational dynamics of the human A adenosine receptor (AAR) while embedded in lipid nanodiscs, providing a more natural environment for the receptors.
- Their findings reveal that AAR can switch between active-like and inactive-like states slowly, and when activated by a ligand, it shows faster dynamics, suggesting this method could be useful for developing new drugs.
Chiral effects originate from the lack of inversion symmetry within the lattice unit cell or sample's shape. Being mapped onto magnetic ordering, chirality enables topologically non-trivial textures with a given handedness. Here, we demonstrate the existence of a static 3D texture characterized by two magnetochiral parameters being magnetic helicity of the vortex and geometrical chirality of the core string itself in geometrically curved asymmetric permalloy cap with a size of 80 nm and a vortex ground state.
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