Clinical and pharmacogenetic features of patients with upper gastrointestinal lesions at a multidisciplinary hospital: the role of nonsteroidal anti-inflammatory drugs.

Objectives: Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed medications, but their use can be associated with a number of adverse reactions, including upper gastrointestinal lesions. The aim of the study was to identify clinical and pharmacogenetic factors associated with upper gastrointestinal lesions, including those linked to NSAIDs, in patients at a multidisciplinary hospital.

Methods: The study included 92 patients (mean age 59.

[Relationships between body composition and hematological parameters in long-living patients with coronary artery disease.].

The study objective to investigate hematological parameters and determine the relationships between these indicators and body composition in centenarians with coronary artery disease. This work is a cross-sectional study, which enrolled 239 patients over 90 years old hospitalized with a diagnosis of coronary artery disease; most of them (67,8%) were women. The age of the patients ranged from 90 to 106 years, averaging 92,8 (±2,5) years.

[Glomerular filtration rate in centenarians with coronary artery disease.].

The study objective was to compare the CKD-EPI, MDRD, BIS1, and Cockroft-Gault equations for calculating GFR, and analyze the various relationships between the glomerular filtration rate and clinical and laboratory parameters in long-living patients with coronary artery disease (CAD). A cross-sectional study of 270 patients from 90 to 106 years old, hospitalized with CAD diagnosis, was performed. The mean estimated GFR according to CKD-EPI was 51,4±14,2 ml/min, MDRD - 50,9±13,4, BIS1 - 38,4±7,7, Cockroft-Gault - 40,6±12,6 ml/min.

[Tumor necrosis factor alfa in very elderly patients with coronary artery disease.].

The results of a study of the concentration of TNF-α as well as the relationship of this cytokine with a number of pathological conditions in very elderly patients with coronary artery disease compared with the control group of patients without CAD are presented in the article. The average group concentration of TNF-α reached 9,2+4,7 pg/ml (from 3,9 to 31,9 pg/ml) with normal TNF-α values of less than 8,1 pg/ml. An increase in the level of TNF-α was detected in 54,6% of patients.

[Bone mineral density in long-living patients with coronary artery disease.].

The results of cross-sectional study aimed to investigate bone mineral density (BMD) in 202 patients over 90 years old with coronary artery disease are presented in this atricle. Normal BMD indices in the lumbar spine were observed in 40,9%, osteoporosis - in 26,9%, osteopenia - in 32,2% of patients. Normal BMD indices in the proximal femur were observed in 21,3%, osteoporosis - in 39,9%, and osteopenia - in 38,8% of patients.