[Application of gepacef comby for an acute surgical diseases of organs of the hepatopancreatobiliary zone].

The experience of application of the III generation cephalosporine Gepacef comby (cefoperazone/sulbactam, manufactured by Corporation "ARTERIUM", Ukraine) in complex of empirical therapy of an acute surgical diseases of the hepatopancreatobiliary zone organs is presented. Efficacy of the preparation was confirmed by the body temperature normalization on the third postoperative day in 77.3% patients, clinico-laboratory indices on the tenth day--in 95.

[The role of immune disorders in formation of local and systemic complications of severe acute pancreatitis].

There were studied the factors, which initiate the immune response in severe acute pancreatitis, in 57 patients of both gender ageing from 16 to 66 years, in whom the acute pancreatitis severity had constituted 3 marks and more (according to the Ranson criterions). In majority of the patients the combined type of the immune disorders had prevailed. The first stage of the disease was characteristic for metabolic hyperactivity occurrence with raising of HLA-DR+ level as well as of immunoregulating coefficient at the expense of the T-helpers quantity increase.