Publications by authors named "O N Mazko"
Article Synopsis
- The study explores the role of betulin, a triterpene alcohol from birch bark, in improving liver health by normalizing metabolism and reducing oxidative stress, particularly in cases of acute toxic hepatitis.
- Researchers conducted experiments on male Wistar rats, dividing them into groups to assess the effects of betulin-enriched mayonnaise on blood biochemistry and liver structure.
- Key parameters evaluated included blood glucose, cholesterol, liver enzyme activities, and oxidative stress indicators, with the aim of demonstrating betulin's hepatoprotective and antioxidant properties.
The effect of carnosine on MMP-2 activity and oxidative stress in the kidneys in experimental urate nephrolithiasis was studied. Urate nephrolithiasis was modeled in Wistar rats by intragastric administration of a mixture of oxonic and uric acids. Carnosine was administered intragastrically through a tube in a dose of 15 mg/kg.
View Article and Find Full Text PDFWe studied the effect of tripeptide Leu-Ile-Lys on kidney function in rats with experimental diabetes mellitus modeled by single intraperitoneal administration of streptozotocin (65 mg/kg). The tripeptide was intragastrically administrated in a dose of 11.5 mg/kg from week 5 to week 8 of the pathological process.
View Article and Find Full Text PDFThe prospect of using the antioxidant dipeptide carnosine for the treatment of urate nephrolithiasis was evaluated. Urate nephrolithiasis was modeled in rats by intragastric administration of a mixture of oxonic and uric acids. Carnosine was administered intragastrically through a tube in a dose of 15 mg/kg.
View Article and Find Full Text PDFWe studied the effect of tripeptide Leu-Ile-Lys on the course of chronic 16-week oxalate nephrolithiasis in rats modeled by administration of 1% ethylene glycol solution in drinking water for 16 weeks. The tripeptide Leu-Ile-Lys obtained by chemical synthesis (sample purity ≥98%) was administered intragastrically through a probe in a dose of 11.5 mg/kg in 1 ml saline.
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