Publications by authors named "O N Li"
KDM5D is a gene implicated in spermatogenic failure and sex-related differences in colon cancer progression, though its role in spermatogenesis remains unclear. We successfully generated a KDM5D knockout human embryonic stem cells using CRISPR/Cas9 technology. This knockout cell line provides a valuable model for studying KDM5D's function in spermatogenesis and its influence on sex differences in various diseases.
View Article and Find Full Text PDFAll-solid-state chloride-ion batteries promise high theoretical energy density and room-temperature operation. However, conventional Sn anodes suffer from low material utilization attributed to large particle size and volume expansion. Here, nano-sized Sn particles in an N-doped carbon framework are used as an anode, resulting in ∼12% higher capacity compared to conventional Sn, due to improved Sn utilization and suppression of volume expansion.
View Article and Find Full Text PDFContrast-enhanced mammography (CEM) is an advanced emerging imaging technique that uses iodine contrast medium to improve breast cancer detection. Understanding CEM artefacts and pitfalls is important to prevent diagnostic misinterpretation. This article aims to provide a comprehensive review of the artefacts and potential diagnostic pitfalls encountered in CEM, focusing on their characteristic imaging features and strategies to mitigate these issues.
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- Developed a nonbiohazardous simulator for ultrasound-guided percutaneous nephrolithotomy using expert feedback and modern education theory.
- A prototype was created with realistic anatomical features through 3D printing and hydrogel molding, and validated by expert surgeons and participants in multicenter trials.
- The simulator showed high satisfaction ratings and significant skill improvements for residents, making it an effective training tool for urologic education.
Article Synopsis
- The study investigates genomic changes in a key yeast used in biotechnology under spontaneous and induced mutagenic conditions.
- Findings highlight a mutation rate of about 4 × 10 events per base pair per cell division, with specific patterns like C-to-T transitions as the most common spontaneous mutations.
- Exposure to mutagens like UV light and Zeocin significantly increases mutation rates, with Zeocin leading to unique substitution patterns and a higher frequency of insertions and deletions.