[The duration of preservation of plague pathogen strains with a different plasmid kit from a Central Caucasian high-altitude natural focus in the organism of citellophilus tesquorum fleas and the possibility of their transmission to laboratory animals].

Two plasmid variants of the main subspecies of the plague microbe circulate in a Central Caucasian high-altitude natural focus of plague. The strains of one plasmid variant fully correspond to the main subspecies of the plague pathogen in their characteristics. Those of the other are auxotrophic for proline, weakly virulent to one or both species of laboratory animals.

[Effects of theraphthal-Lio on hemostasis in experimental animals].

Teraphtal-Lio (Tph) exerted a toxic dose-dependent effect on the hemostatic system. Treatment of experimental animals with maximum tolerated and highly toxic doses was followed by acute DVS syndrome formation involving a hemophilic condition, soaring activated partial prothrombin time, absence of fibrinogen, sharp rise in fibrinogen degradation product and D-dimer matched by fall in thrombocyte count. No toxic influence on the hemostatic system was registered when Tph doses recommended for humans in the course of phase II clinical trials were administered to animals.

[Toxicity of binary "theraphthal-Lio+ascorbic acid" (TPH+AA) catalytic system during different methods of regional intra-arterial administration in dogs].

A binary teraphtal-Lio + ascorbic acid (Tph + AA) catalytic system has been tested for untoward side-effects using three procedures of regional intraarterial infusion on dogs. On the basis of the data on local-tissue and overall toxicity, an optimal one was selected and recommended for clinical use.

[Preclinical toxicological study of theraphthal-Lio and binary catalytic system "theraphthal-Lio+ascorbic acid"].

Pre-clinical toxicologic studies were conducted of a new drug teraphtal-Lio (TPh) and a teraphtal-Lio + ascorbic acid (TPh + AA) catalytic system recommended for binary catalytic therapy of malignant tumors. Quantitative criteria for "acute" and "chronic" toxicity of TPh and TPh + AA were established, which describe their toxic effects in single or multiple application. The coefficient of specific sensitivity and cumulation index for TPh and TPh + AA were determined.