[The role of mitochondria in NO-dependent regulation of Na+, K+ -ATP activity in the rat aorta].

In experiments in vivo we studied the interaction between two ion-transporting mechanisms of cardiovascular system--Na+, K+ -ATPase of rat aorta and Ca2+ -uptake system of mitochondria in short-term response to different doses of NO donor, nitroglycerine (NG). The activity of the Na+, K+ -ATPase was determined in rat aorta, and mitochondrial uptake of Ca2+ was studied in rat heart mitochondria assuming that metabolism induced by NO in cardiac mitochondria is similar to that in rat aortic mitochondria. The data show a coordinated dose-dependent action of NG on Na+, K+ -ATPase activity as well as Ca2+ -uptake in mitochondria.

[Effect of nitric oxide on Na+, K(+)-ATPase in the aorta tissue of rats].

The influence ofnitric oxide on Na+,K(+)-ATPase activity in rat aorta was studied by means of stimulation of endogenous NO synthesis after injections of bacterial lipopolysaccharide (LPS) and pharmacological NO donor nitroglycerine (NG). It was shown that NO action on Na+,K(+)-ATPase in vivo is dose-dependent. Stimulation of the endogenous NO synthesis by LPS as well as the administration of low doses of NG lead to the activation of Na+,K(+)-ATPase and favor the conclusion that NO-dependent Na+,K(+)-ATPase stimulation mediates vasodilatory and hypotensive action of nitric oxide.

[Immunotoxicity of aluminum chloride].

Aluminum chloride was tested for its effect on primary T-dependent humoral immune response. The administration of aluminum chloride in the genotoxic dose (0.04 M) caused in mice a profound immunosuppressive effect accompanied by diminished thymic and splenic cellularity.

[The reference information system "Ecology and aluminum toxicology"].

Views of the toxicity of aluminum to man, animals, and plants and on its behavior in the ecosystems with a changing man-made loading have changed in the past 30 years. Aluminum along with its human medical consequences has been found to present problems on the acid soils in world agriculture. To systematize knowledge and to control information on aluminum and its compounds, the reference information system "Ecology and Aluminum Toxicology" whose structure is based on the developed model of an ecological aluminum cycle was designed.