Myeloid Cell Mobilization and Recruitment by Human Mesothelioma in NSG-SGM3 Mice.

Malignant pleural mesothelioma is a neoplasm that is often detected late due to nonspecific symptoms. This study utilized NSG-SGM3 mice to examine interactions between a human-derived mesothelioma reporter cell line (MZT-Luc2-mCherry) and the host's myeloid compartment. Tumor growth was assessed using optical tomography, while cytokine/chemokine production was analyzed via multiplex assay.

6-Aryl- and 6,7-diaryl-1,3-dimethyl-1-perimidin-2(3)-ones: synthesis, conformational stability, crystal structure and optical properties.

6-Bromo- and 6,7-dibromo-1,3-dimethyl-1-perimidin-2(3)-ones were arylated with arylboronic acids under Suzuki-Miyaura reaction conditions to afford 6-aryl-, 6-bromo-7-aryl- and 6,7-diaryl-1,3-dimethyl-1-perimidin-2(3)-ones. A comparison of the X-ray structural parameters of -diaryl derivatives of 1,3-dimethyl-1-perimidin-2(3)-one, naphthalene and 1,8-bis(dimethylamino)naphthalene (proton sponge) was performed. Based on the data of dynamic H NMR spectroscopy and quantum-chemical calculations, barriers to /-isomerization of 6,7-diaryl-1,3-dimethyl-1-perimidin-2(3)-ones were estimated.

Anion and Substituents Effect on Spectral-Kinetic and Biological Characteristics of Spiropyran Salts.

Spiropyran salts containing a cationic vinyl-3H-indolium moiety are characterized by NIR absorption and fluorescence of their merocyanine forms. This feature makes them promising fluorescent probes and markers for bioimaging. The article focuses on the synthesis and study of the spectral, kinetic and toxic characteristics of such compounds with respect to various substituents in different moieties and the type of anion.

Synthesis, electrochemical properties, and antioxidant activity of sterically hindered catechols with 1,3,4-oxadiazole, 1,2,4-triazole, thiazole or pyridine fragments.

A series of new RS-, RS-CH- and RN-CH-functionalized сatechols with heterocyclic fragments such as 1,3,4-oxadiazole, 1,2,4-triazole, thiazole, or pyridine were synthesized by the reaction of 3,5-di--butyl--benzoquinone or 3,5-di--butyl-6-methoxymethylcatechol with different heterocyclic thiols. The S-functionalized catechols were prepared by the Michael reaction from 3,5-di--butyl--benzoquinone and the corresponding thiols. The starting reagents such as substituted 1,3,4-oxadiazole-2-thiols and 4-triazole-3-thiols are characterized by thiol-thione tautomerism, therefore their reactions with 3,5-di--butyl-6-methoxymethylcatechol can proceed at the sulfur or nitrogen atom.