An Investigation of Novel Series of 2-Thioxo-1,3-dithiol-carboxamides as Potential Antispasmodic Agents: Design, Synthesis via Coupling Reactions, Density Functional Theory Calculations, and Molecular Docking.

This study reports the synthesis of 2-thioxo-1,3-dithiol-carboxamides () under mild conditions at room temperature using HBTU as a coupling agent, which significantly improved amide bond formation. The synthesized compounds were characterized using several analytical techniques, including H and C NMR spectroscopy, and HRMS, confirming their intended structures and structural integrity. A DFT computational study at the B3LYP/6-31G(d,p) level was conducted on the four synthesized compounds to compare their electronic properties and molecular structures.

Design, Synthesis, in vitro and in silico Characterization of 2-Quinolone-L-alaninate-1,2,3-triazoles as Antimicrobial Agents.

Due to the ever-increasing antimicrobial resistance there is an urgent need to continuously design and develop novel antimicrobial agents. Inspired by the broad antibacterial activities of various heterocyclic compounds such as 2-quinolone derivatives, we designed and synthesized new methyl-(2-oxo-1,2-dihydroquinolin-4-yl)-L-alaninate-1,2,3-triazole derivatives via 1,3-dipolar cycloaddition reaction of 1-propargyl-2-quinolone-L-alaninate with appropriate azide groups. The synthesized compounds were obtained in good yield ranging from 75 to 80 %.

MoS nanosheets/silver nanoparticles anchored onto textile fabric as "dip catalyst" for synergistic p-nitrophenol hydrogenation.

Attaining a synergistic merge between the performance of homogenous catalysts and the recyclability of heterogeneous catalysts remains until now a concerning issue. The main challenge is to design efficient, low-cost catalyst with outstanding reusability, facile recovery, and ease of retrieval and monitoring between the reuses. Despite the vast efforts in the development of silver nanoparticle-based catalyst for the reaction of hydrogenation of 4-nitrophenol, the aforementioned criteria are infrequently found in a chosen system.

[Leiomyosarcoma of the gingiva. Apropos of a case. Review of the literature].

Leiomyosarcoma (LMS) accounts for 7% of all smooth tissue sarcomas. The rarity of smooth muscle cells in the oral cavity makes LMS a rare tumor in this localization. We report a case of gingival LMS in a 43-year-old woman.