Locomotor-Reducing, Sedative, and Antidepressant-Like Effects of Confectionery Flavours Coumarin and Vanillin.

Coumarin and vanillin are compounds with comforting scents and are often used for flavouring confectionery. The locomotor-reducing, sedative, and antidepressant-like effects of coumarin and vanillin vapours administered via inhalation were investigated. Coumarin and vanillin showed all these effects.

Corrigendum: Identification of an alternative glycyrrhizin metabolite causing liquorice-induced pseudohyperaldosteronism and the development of ELISA system to detect the predictive biomarker.

[This corrects the article DOI: 10.3389/fphar.2021.

Evaluation of the Amounts of Sennosides A and B in Rhubarb-containing Kampo Medicines to Create a Ranking of Kampo Medicines for Appropriate Selection of Laxatives.

Objectives: To evaluate 20 Kampo medicines, which comprised 6 formulas, Otsujito, Junchoto, Tokakujokito, Bofutsushosan, Mashiningan, and Keishikashakuyakudaioto, from 7 brands, to create a ranking of Kampo medicines for appropriate selection of laxatives.

Methods: The amounts of sennosides A and B, the important components showing laxative effects contained in Kampo medicines, were analysed using High Performance Liquid Chromatography.

Results: We found that the amounts of sennosides A and B were different among brands, even when they had the same formula.

Identification of an Alternative Glycyrrhizin Metabolite Causing Liquorice-Induced Pseudohyperaldosteronism and the Development of ELISA System to Detect the Predictive Biomarker.

Liquorice is usually used as crude drug in traditional Japanese Kampo medicine and traditional Chinese medicine. Liquorice-containing glycyrrhizin (GL) can cause pseudohyperaldosteronism as a side effect. Previously, we identified 18-glycyrrhetyl-3--sulfate () as a GL metabolite in Eisai hyperbilirubinuria rats (EHBRs) with the dysfunction of multidrug resistance-related protein (Mrp2).

Appetite-enhancing effects of inhaling cinnamon, clove, and fennel essential oils containing phenylpropanoid analogues.

Cinnamon, clove, and fennel are commonly used as spices and herbal medicines, and one of their medicinal uses is as aromatic stomachics. We investigated the effect on appetite in mice of inhaling volatile compounds contained in essential oils extracted from herbal medicines used as aromatic stomachics. The appetite-enhancing effects of cinnamon and fennel essential oils were similar to those of their main components trans-cinnamaldehyde and trans-anethole, respectively.