[Idiopathic hypertrophic pachymeningitis: a diagnostic dilemma].

Introduction: Idiopathic hypertrophic pachymeningitis (IHP) is a rare fibrosing inflammatory process of unknown pathogenesis that causes diffuse thickening of the duramater. In spite of the fact that this pathological entity has been linked to specific etiological agents such as syphilis, tuberculosis, mycosis and sarcoidosis, In recent years there has been an increase in the number of patients with IHP of undetermined cause.

Case Report: 58 year-old female with a long date history of oppressive headaches, frontally located at first, and later generalized, accompanied by weakness and asthenia; urinary incontinence, dizziness, vomiting, and gait ataxia.

[Cerebrovascular disease: its relationship with cardiovascular and renal pathology in 134 clinical autopsies].

Objective: To establish the relationship between cardiopathy and chronic nephropathy, and cerebral vascular pathology in clinical necropsies performed in adult patients.

Material And Methods: The protocols of 861 clinical autopsies done during the lapse 1990-2000 were reviewed, of these, 134 cases with diagnosis of cerebrovascular disease (CVD) were selected. Analyzed features included: neuropathological study of CVD, renal and cardiovascular pathology, and cause of death.

[Sudanophilic cavitating leukodystrophy: adult familial form].

Sudanophilic cavitating leukodystrophy is an unusual disorder of the cerebral white matter, clinically characterized by deafness, mental retardation, behavioural alterations and lesions of the descending long tracts. Neuropathological features include: extensive subcortical and deep central demyelination, conspicuous astrocytosis and macro and micro cavitation. We describe a 34 year-old male with personal and family history, clinical features and neuropathological changes consistent with Sudanophilic cavitating leukodystrophy.

[Creutzfeldt-Jakob disease. Report of 2 cases].

The authors report two cases of Creutzfeldt Jakob disease in a 48 year old woman and a 60 year old man. This demential disorder is induced by a non conventional virus and its characterized from a clinical point of view by progressive dementia, myoclonus and seizures, it follows a subacute course with progressive deteriorization that invariably leads to death. Neuropathological features include: neuronal loss, astrocytosis and neuropil vacuolization in cortical areas of the brain.