Publications by authors named "O Miyamoto"
Brain edema causes abnormal fluid retention and can be fatal in severe cases. Although it develops in various diseases, most treatments for brain edema are classical. We analyzed the impacts of age and gender on the characteristics of a water intoxication model that induces pure brain edema in mice and examined the model's usefulness for research regarding new treatments for brain edema.
View Article and Find Full Text PDFNeuroprotective therapeutic potential for restoring dysregulated microRNA (miRNA) expression has previously been demonstrated in a gerbil cerebral infarction model. However, since temporal changes in miRNA expression profiles following stroke onset are unknown, miRNAs proving to be useful therapeutic targets have yet to be identified. We evaluated cognitive function, hippocampal neuronal cell death, and microarray-based miRNA expression profiles at 5, 9, 18, 36, and 72 h after 5-min whole brain ischemia in gerbils.
View Article and Find Full Text PDFHistopathological changes occur in the brainstem during the early stages of Alzheimer's disease (AD), with the pathological changes of the brain lesions ascending progressively in accordance with the Braak staging system. The senescence‑accelerated mouse prone 8 (SAMP8) mouse model has been previously used as a model of age‑dependent neurodegenerative diseases, including AD. In the present study, microRNAs (miRNAs) that were upregulated or downregulated in SAMP8 brainstems were identified using miRNA profiling of samples obtained from miRNA arrays.
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- Progressive supranuclear palsy (PSP) is a challenging neurodegenerative disorder characterized by symptoms like balance issues, vision problems, voice difficulties, and dementia, with no clear diagnostic biomarkers.
- The study investigated cerebrospinal fluid microRNAs (miRNAs) in 11 PSP patients, using a microarray chip to analyze expression levels, finding 38 miRNAs significantly upregulated and one downregulated compared to controls.
- Specific miRNAs associated with disease stages were linked to biological pathways like ubiquitin-proteasome and autophagy, suggesting they could play a role in PSP's pathogenesis and aid in future diagnostic efforts.
Spinal cord injury (SCI) induces severe motor and sensory dysfunction. We previously showed the neuroprotective effects of COA-Cl, a novel synthesized adenosine analog, in a rat stroke model. In this study, we evaluated the neuroprotective effects of COA-Cl in acute phase of SCI.
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