Publications by authors named "O Mir"
Article Synopsis
- The study highlights that body weight and sex can significantly impact how anticancer drugs are processed in the body, yet the extent of these differences remains unclear.
- A systematic review of 112 studies identified significant pharmacokinetic (PK) differences for 14 out of 99 examined anticancer agents, although no studies currently assess how these differences impact drug efficacy or safety.
- The findings suggest that developing sex-specific dosing strategies for anticancer drugs could improve their risk-benefit ratio for patients.
Article Synopsis
- Desmoplastic small round cell tumor (DSRCT) is an aggressive form of cancer linked to a specific genetic factor called EWS-WT1, and treatment options have not improved significantly in over 20 years.
- Researchers conducted a comprehensive drug sensitivity test on DSRCT cells and found that they respond well to PARP and ATR inhibitors, both alone and in combination, showcasing these treatments across various models.
- The study reveals that the combination of these inhibitors causes significant DNA damage and activates immune responses, suggesting that targeting EWS-WT1 could be an effective strategy in treating DSRCT.
Serotonin reuptake inhibitor antidepressants such as fluoxetine are widely used to treat mood disorders. The mechanisms of action include an increase in extracellular level of serotonin, neurogenesis, and growth of vessels in the brain. We investigated whether fluoxetine could have broader peripheral regenerative properties.
View Article and Find Full Text PDFBackground And Purpose: Tenecteplase is the thrombolytic drug of choice for acute ischemic stroke (AIS) as it has unique pharmacologic properties, along with results demonstrating its non-inferiority compared to alteplase. However, there are contradictory data concerning the risk of intracranial hemorrhage. The purpose of the study was to report the rate and patterns of symptomatic intracranial hemorrhage (sICH) in AIS patients after thrombolysis with tenecteplase compared to alteplase.
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