[Example of a phase IV trial involving several physicians and aiming at answering a scientific question: EOL].

The aim of this trial was to test the hypothesis that a reduced number of doses improves compliance in current medical practice. Compliance with twice a day dosage was compared with compliance with three doses a day. Two bioequivalent presentations of nicardipine were used, the regular presentation (t.

Comparison between a bid and a tid regimen: improved compliance with no improved antihypertensive effect. The EOL Research Group.

Objectives: To compare compliance with an antihypertensive treatment administered either twice daily or three times daily. The two formulations of the antihypertensive treatment used (nicardipine) "regular tablets" (t.d.

[Effect of the captopril-hydrochlorothiazide combination on blood lipids. Study in a population of hypertensive hyperlipidemic patients].

In this placebo-controlled, randomized double-blind, parallel study the effects of the fixed captopril 50 mg + hydrochlorothiazide (HCTZ) 25 mg combination on plasma lipids were assessed in 42 hypertensive, type IIa or IIb hyperlipidaemic patients on diets. Some patients received oral hypolipidaemic treatment and some did not. Blood pressure and plasma lipids levels were measured before and after 1, 2 and 3 months of treatment.