Publications by authors named "O Meijer"
Glucocorticoids and androgens affect each other in several ways. In metabolic organs such as adipose tissue and the liver, androgens enhance glucocorticoid-induced insulin resistance and promote fat accumulation in male mice. However, the direct contribution of the androgen receptor (AR) to these effects is unknown.
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- - Narcolepsy type 1 (NT1) is characterized by low hypocretin levels and changes in stress hormone activity, particularly a loss of corticotrophin-releasing hormone (CRH) linked to the body's stress response system.
- - A study involving NT1 patients and healthy controls utilized the Trier Social Stress Test to measure physiological and psychological responses to stress, including changes in ACTH, cortisol, heart rate, and subjective stress levels.
- - Results indicated participants with NT1 felt more stressed, but their hormone and heart rate responses were similar to controls, although men with NT1 had notably lower cortisol levels after stress than their control counterparts, suggesting further exploration is necessary for understanding CRH's role and gender effects
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- - Mineralocorticoid (MR) and glucocorticoid receptors (GR) are key transcription factors involved in various processes like stress response, hormonal signalling, mood, cognition, and memory, despite their structural differences, especially in the N-terminal domain.
- - A study using a Proximity Ligation Assay (PLA) on murine neuroblastoma (N2A) cells showed that continuous stimulation with corticosterone (CORT) results in MR-GR complexes accumulating at the cell nucleus's periphery, particularly when the receptor's ligand binding domain is truncated.
- - Interestingly, while MR-GR complex localization changed with receptor activation, there wasn't a straightforward link between where these complexes were located in the nucleus and
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- A study examined the emotional and skin-related symptoms in five patients with cutaneous T-cell lymphoma undergoing glucocorticoid treatment, finding that emotional disturbances often accompany this therapy.
- Results showed that as treatment progressed, positive emotions declined, leading to increased irritation and itchy skin the following day.
- The findings suggest that reduced positive emotions at the end of glucocorticoid treatment may be linked to lower energy and motivation, potentially worsening skin-related issues.
Objective: Endogenous glucocorticoid levels display a strong circadian rhythm, which is often not considered when synthetic glucocorticoids are prescribed as anti-inflammatory drugs. In this study we evaluated the effect timing of glucocorticoid administration, i.e.
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