Draft genome of a human-derived that caused spontaneous disseminated infection in a mouse.

We present the draft genome of a novel human-derived strain isolated from a healthy control human microbiota that, when put into a mouse, spontaneously disseminated from the gut to the kidneys.

Aromatic ointments for the common cold: what does the science say?

Background: Upper respiratory tract infections occur with an annual incidence of 17.2 billion cases globally. The negative impact that symptoms have on sleep is thought to slow the recovery process.

Little time, lasting impact: Bereaved caregiver perceptions of legacy in perinatal and infant loss.

Background: Legacy interventions are standard in most children's hospitals, but little is known about how bereaved parents understand and describe the concept of legacy that these interventions are designed to Address. The aim of this qualitative study was to understand the legacy experiences and perceptions of parents who have experienced perinatal or early infant (less than three months of age) loss.

Methods: Grounded in constructionist epistemology and phenomenological qualitative traditions, ten bereaved parents completed an in-depth phenomenological interview regarding their perceptions of and experiences with the legacy of their deceased child.

Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells.

Background: Extracellular microRNAs enter kidney cells and modify gene expression. We used a Dicer-hepatocyte-specific microRNA conditional-knock-out (Dicer-CKO) mouse to investigate microRNA transfer from liver to kidney.

Methods: Dicer mice were treated with a Cre recombinase-expressing adenovirus (AAV8) to selectively inhibit hepatocyte microRNA production (Dicer-CKO).

Absence of MyD88 from Skeletal Muscle Protects Female Mice from Inactivity-Induced Adiposity and Insulin Resistance.

Objective: Inactivity and inflammation are linked to obesity and insulin resistance. It was hypothesized that MyD88 (mediates inflammation) knockout from muscle (MusMyD88 ) would prevent, whereas miR146a (MyD88 inhibitor) would exacerbate, inactivity-induced metabolic disturbances.

Methods: Cre-control, MusMyD88 , and miR146a mice were given running wheels for 5 weeks to model an active phenotype.