Publications by authors named "O Martinez-Macias"
Article Synopsis
- SERINC5 plays a crucial role in limiting certain viruses' infectivity, but its regulation during viral infection, especially with SARS-CoV-2, is not well understood.
- Recent findings show that SERINC5 levels drop in COVID-19 patients, and this decrease might be linked to small viral RNAs (svRNAs) produced by SARS-CoV-2, which can bind to SERINC5 mRNA and lower its expression.
- Anti-svRNA treatments could potentially restore SERINC5 levels and reduce viral protein levels, suggesting a new therapeutic approach for enhancing the innate immune response during COVID-19.
Objectives: To describe clinical characteristics of fracture patients, including a closer look to hip fracture patients, and determine how epidemiological variables may have influenced on a higher vulnerability to SARS-CoV-2 infection, as the basis for the considerations needed to reintroduce elective surgery during the pandemic.
Design: Longitudinal prospective cohort study.
Setting: Level I Trauma Center in the East of Spain.