Engineered ipilimumab variants that bind human and mouse CTLA-4.

Testing of candidate monoclonal antibody therapeutics in preclinical models is an essential step in drug development. Identification of antibody therapeutic candidates that bind their human targets and cross-react to mouse orthologs is often challenging, especially for targets with low sequence homology. In such cases, surrogate antibodies that bind mouse orthologs must be used.

Postoperative Activity Restrictions After Reconstructive Pelvic Surgery.

Importance: Restrictive physical activity after pelvic reconstructive surgery is recommended, although the optimal duration and intensity are not standardized.

Objective: This systematic review and meta-analysis aimed to evaluate the existing literature comparing clinical outcomes for liberal postoperative physical activity versus standard of care, defined as restricted postoperative physical activity, after pelvic reconstructive surgery.

Study Design: PubMed, CENTRAL, Scopus, Web of Science, and CINAHL databases were searched for observational and randomized studies comparing liberal postoperative physical activity and standard of care in women undergoing pelvic reconstructive surgery, reporting anatomic and functional outcomes.

Childcare subsidy receipt and reduced emotional neglect: Examining parents' enhanced self-efficacy as a mediator.

Background: Each year 1.5 million children receive childcare subsidized under the Child Care and Development Fund, which supports working parents with low income in affording childcare; such policies hold promise for reducing child neglect.

Objective: The current study sought to examine how receiving childcare subsidies might reduce emotional neglect by supporting working parents' self-efficacy.