Publications by authors named "O Marco"
Article Synopsis
- * Historical famines, particularly the Dutch Hunger Winter and the Great Chinese Famine, provide critical insights into the impacts of prenatal starvation on health across generations.
- * There is some disagreement among studies about the specific risks and timing of starvation during pregnancy, and gender differences further complicate the understanding of these effects.
Preeclampsia and hypertensive disorders of pregnancy complicate 3 to 5% of all pregnancies. Chronic kidney disease (CKD), at any stage, reportedly affects 3% of women in childbearing age but most of the time is underdiagnosed, especially in asymptomatic early stages. The link between preeclampsia/hypertensive disorders of pregnancy and CKD is bidirectional and women experiencing a preeclampsia/hypertensive disorder of pregnancy episode are at higher risk for developing CKD later in life, as well as metabolic and cardiovascular diseases.
View Article and Find Full Text PDFBackground: The nephrotoxic effects of non-steroidal anti-inflammatory drugs (NSAIDs) are widely acknowledged. In particular, diclofenac is the most commonly prescribed NSAIDs, but no previous findings of electrolyte disturbances were reported following its administration.
Case Report: We presented the case of a man who experienced significant weakness associated with severe deficiencies in potassium, calcium, and magnesium after misusing diclofenac because of severe back pain.
Overcoming treatment-resistant depression with machine-learning based tools: a study protocol combining EEG and clinical data to personalize glutamatergic and brain stimulation interventions (SelecTool Project).
Front Psychiatry
July 2024
Article Synopsis
- Treatment-Resistant Depression (TRD) is a significant health issue that's hard to tackle due to its complex nature and varied symptoms, prompting the need for better treatment strategies.
- The SelecTool Project is introduced as a computational tool that combines clinical data, EEG, and blood biomarkers using machine learning to personalize TRD treatments, specifically focusing on esketamine nasal spray and accelerated repetitive Transcranial Magnetic Stimulation.
- The project involves two main phases: first, a study with 100 TRD subjects to evaluate the effectiveness of treatments, and then training the tool to assist in managing an additional 20 subjects, ultimately aiming to improve TRD treatment outcomes through advanced data analysis.
Introduction: Systemic sclerosis (SSc) is characterized by microvascular damage of skin and internal organs with chronic hypoxia and release of cytokines and hormones such as neutrophil gelatinase-associated lipocalin (NGAL), fibroblast growth factor-23 (FGF-23) and Klotho. Aim of the study was to evaluate FGF-23, Klotho and NGAL serum levels in SSc patients and healthy controls (HC) and to evaluate serum levels changes of FGF-23, Klotho and NGAL after Iloprost.
Methods: Twenty-one SSc patients and 20 HC were enrolled.