Publications by authors named "O M van der Meer"
Various groups of chemicals that we encounter in every-day life are known to disrupt the endocrine system, such as estrogen mimics that can disturb normal cellular development and homeostasis. To understand the effect of estrogen on intracellular protein dynamics and how this relates to cell proliferation, we aimed to develop a quantitative description of transcription factor complexes and their regulation of cell cycle progression in response to estrogenic stimulation. We designed a mathematical model that describes the dynamics of three proteins, GREB1, PR and TFF1, that are transcriptionally activated upon binding of 17β-estradiol (E2) to estrogen receptor alpha (ERα).
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- Extracorporeal CPR is a method used to restore blood flow and oxygen to patients with cardiac arrest who don’t regain spontaneous circulation, but its effectiveness on survival and neurological outcomes is unclear.
- A randomized trial in the Netherlands compared extracorporeal CPR with conventional CPR in patients aged 18 to 70 who experienced out-of-hospital cardiac arrest and received bystander CPR.
- The results showed that after 30 days, 20% of patients in the extracorporeal CPR group had a favorable neurologic outcome compared to 16% in the conventional CPR group, indicating similar outcomes for both methods.
Background: Acute heart failure patients are often encountered in emergency departments (ED) from 11% to 57% using emergency medical services (EMS). Our aim was to evaluate the association of EMS use with acute heart failure patients' ED management and short-term outcomes.
Methods: This was a sub-analysis of a European EURODEM study.
Objective: Lower respiratory tract infection (LRTI) is a frequent cause of dyspnoea in EDs, and is associated with considerable morbidity and mortality. We described and compared the management of this disease in Europe and Oceania/South-East Asia (SEA) cohorts.
Methods: We conducted a prospective cohort study with three time points in Europe and Oceania/SEA.
Background/aim: To describe seasonal variations in epidemiology, management, and short-term outcomes of patients in Europe presenting to an emergency department (ED) with a main complaint of dyspnea.
Materials And Methods: Anobservational prospective cohort study was performed in 66 European EDs which included consecutive patients presenting to EDs with dyspnea as the main complaint during 3 72-h study periods. Data were collected on demographics, comorbidities, chronic treatment, prehospital treatment, mode of arrival of patient to ED, clinical signs at admission, treatment in the ED, ED diagnosis, discharge from ED, and in-hospital outcome.