[The effect of phenazepam on the pancreatic excretory function in thermal stress].

The excretory function of the pancreas was studied on albino rats during thermal stress and ACTH (corticotropine) administration. Stress inhibited the enzyme-synthesizing and enzyme-secreting functions of the gland. The tranquilizer phenazepam influencing the GABA-ergic brain systems exerted a protective effect on pancreatic exosecretion in stress and its strength depended on the administration regimen of the drug.

[The participation of cholinergic structures at different levels in shaping the immediate adaptation of the pancreas to food quality in ontogeny].

The experiments on rats showed that the urgent enzymatic adaptations of the pancreas to the quality of food have not been inherent, but have been created in the ontogeny. These adaptations are usually absent during transition to the definitive feeding (23rd day of life). Adaptation for protein stimulant appears in the moment of taking away of mother (30th day of life) and becomes persistent for protein and fat stimulants by the 90th day of life (adult rats).

[Cholinergic mechanisms in the development of hydrolysis-transport function of the small intestine during ontogeny of intact and stress-exposed rats].

The blockade of peripheric m-cholinoreceptors by atropine in early periods after rat birth is shown to delay the further development of intestinal transport and also hydrolysis-transport mechanisms for carbohydrates.

[Effect of ethionine on intestinal enzymatic activity in adult rats].

The activity of intestinal enzymes (dipeptidase, monoglyceride lipase, amylase, invertase) was studied in intestinal mucosa homogenates from different parts of the small intestine in adult rats 24, 48, and 72 hours after a single intraperitoneal administration of ethionine in a dose of 500 mg/kg bw. 24 hours after antimetabolite administration there was a decrease in the abrasion of the small intestinal mucosa. The enzyme-forming function of the small intestine appreciably changed throughout the observation period.

[Effect of different food stimuli on pancreatic exocrine function in ontogeny].

The fermentative adaptation of the pancreas to the quality of food through determination of the amylase, lipase and proteases activity in the contents of the small intestine and the gland homogenate on an empty stomach and 2 hours feeding on the egg white, bread and walnuts were studied in chickens aged 1-60 days. The 1-2 day old chicken are shown to lack the ability to adapt the gamut of pancreatic enzymes to the quality of the stimulant. This ability appears on the 5th day and becomes persistent by the 20th day of life.