Phase I trial of menadiol diphosphate (vitamin K3) in advanced malignancy.

Based on the activity of menadione (M) in the human tumor stem cell assay, we conducted a phase I trial of M in patients with advanced cancer. Forty patients (19 men, 21 women) were treated with 90 courses of M; 82 treatment courses are evaluable for toxicity. The median patient age, Karnofsky performance status, and number of prior chemotherapy regimens were 61 years (range 32-74 years), 80% (range 50-100%), and two, respectively.

Marital disruption--the welfare of the children thereafter in Nigeria.

Departure from the traditional society is being witnessed in Nigeria and many cultural values and control are being lost. Many marriages are contracted between the individuals as opposed to between families, and so poorly withstand the test of time and stress of modern day living, hence more children witness family disruption than before. One thousand randomly selected State Social Welfare case records were studied in depth and information regarding the socioeconomic and demographic characteristics of the families, the nature of their problems, welfare status of the children including paternal contribution for their maintenance were extracted, collated and analyzed.

AIDS: awareness and blood handling practices of health care workers in Lagos, Nigeria.

A questionnaire survey of 260 health care workers from 13 randomly selected health care facilities was undertaken. Their knowledge, attitude, belief and blood handling practices regarding HIV/AIDS were enquired about. Virtually all (99.

Ethnographic study on childhood diarrhoeal diseases in a rural Nigerian community.

Mothers in thirty households in a rural Nigerian community were subjected to ethnographic studies on food handling practices as they relate to diarrhoeal diseases in children. The study had a first phase of three open-ended unstructured interviews each lasting about 2 hours and a second phase of direct observations on food handling practices during preparation, administration and storage by mothers. Results indicated that as many as 20 (66.

Wife battering in Nigeria.

Objective: To determine the prevalence, types and regularity of spouse abuse among Nigerian women. The effects of socio-economic status, education and alcohol consumption were also investigated.

Method: Questionnaire survey of 1000 randomly chosen Nigerian women was undertaken.