Publications by authors named "O M Munoz"
The primary immunological readout for clinical trials of R21/MatrixM™ malaria vaccine, is total IgG antibody specific to the central four amino acid NANP repeat region of the circumsporozoite protein. A multiplexed assay, which includes NANP, was developed and validated for four antigens representing components of the R21 immunogen. Initial assay optimisation included validation of the HBsAg international standard.
View Article and Find Full Text PDFSpanish speakers rely on social media for health information, with varying quality of its content. This study evaluates the reliability, completeness, and quality of type 2 diabetes (T2D) information available in Spanish-language videos on YouTube and Facebook. Analytical observational study that included Spanish-language videos on TD2 available on Facebook and YouTube.
View Article and Find Full Text PDFBackground: Continuous glucose monitoring (CGM) with minimally invasive devices plays a key role in the assessment of daily diabetes management by detecting and alerting to potentially dangerous trends in glucose levels, improving quality of life, and treatment adherence. However, there is still uncertainty as to whether CGMs are accurate enough to replace self-monitoring of blood glucose, especially in detecting episodes of hypoglycemia.
Objectives: Evaluate clinical, numerical accuracy, sensitivity, and specificity of the CGM devices commercially available when compared to the reference standard of arterial or venous blood glucose.
Article Synopsis
- * In addition to its effects on glucose metabolism, insulin affects reproductive health by suppressing the secretion of gonadotropins from the pituitary gland, particularly in states of high insulin levels (hyperinsulinemia).
- * Research using LβT2 gonadotropic cells reveals that insulin stimulation leads to the unexpected movement of GLUT1 transporters to the cell membrane, occurring independently of the typical Akt signaling pathway, suggesting a complex role for insulin in these cells.
Background: Several models have been developed to assess bleeding risk in patients with venous thromboembolism, such as HAS-BLED, but their external validity has not been adequately assessed.
Objective: The objective of the study was to evaluate the discriminative ability and calibration of the HAS-BLED scale for predicting 1-month bleeding risk in patient's anticoagulated for venous thromboembolism.
Materials And Methods: External validation study of a prediction model based on a retrospective cohort of patients with venous thromboembolism treated between November 2019 and January 2022.