[The participation of the hypophyseal-adrenal system in regulating alpha 2-adrenoreceptor reactivity. The effects of extreme exposures and alpha 2-adrenoblockaders].

The simulation of the hypo- and hyperactivity of the hypophysis-adrenocortical system induced considerable changes in the reactivity of alpha 2-adrenoceptors, as well as in the resistance of the organism to stressful influences. The findings support the assumption that the blockade of alpha 2-adrenoceptors is one of the key features in the adaptive mechanism of the glycocorticoid hormones action.

[The reactivity of postsynaptic alpha 1- and alpha 2-adrenoreceptors and arterial pressure in acute pancreatitis].

Experiments were conducted on pithed rats with acute pancreatitis and on falsely operated on animals (ether-laparotomy stress) to study the reactivity of vascular alpha 1- and alpha 2-adrenoreceptors and its role in changes in arterial pressure. Selective change in the reactivity of alpha 2-adrenoceptors alone was revealed in both groups. Stable reduction of vascular alpha 2-adrenergic reactivity (by 57-58%) and arterial pressure was recorded in animals with acute pancreatitis.

[The action of azepoxole on central alpha 2-adrenoreceptors].

The effect of adrenomimetics on the central alpha 2-adrenoreceptors responsible for mydriasis was studied. It was found that alpha 2-adrenomimetic azepoxole (BHT-933) exerts no effect on the central alpha 2-adrenoreceptors providing mydriasis.