[Modified lipoproteins--their types and role in atherogenesis].

In the performed clinical and experimental investigation there were determined the significance of lipoprotein modification in atherogenesis and the mechanisms of blood atherogenicity development. The pronounced changes of total blood cholesterol and the spectrum of lipoproteins in patients with coronary atherosclerosis were not regular and were noted only in 40-55% cases. The most regular was the increasing of blood atherogenicity, reflecting the appearance of the great amount of modified lipoproteins.

[Calcium metabolism and the diastolic rigidity status of the myocardium in patients with ischemic heart disease under the influence of calcium antagonist treatment].

The calcium (Ca2+) metabolism disorder in IHD patients which manifests itself in an increase of blood serum content of ionized Ca2+ and its accumulation in red blood cells and in cardiomyocytes is accompanied by myocardial functional disturbances as an increase in myocardial stiffness. The increase both of ionized Ca2+ content in blood plasma and left ventricular rigidity are prerequisites for the antianginal effect of corinfar. Normalization of Ca2+ content in blood plasma by corinfar can serve as a criterion of therapy efficiency of IHD patients.