Publications by authors named "O M Lesch"
Objective: We investigate the prevalence of five affective temperaments (depressive, cyclothymic, hyperthymic, irritable, and anxious) in a large sample of cancer patients and associations of temperament with cancer site as well as the impact of temperament on overall survival of cancer patients.
Methods: Data for this prospective cohort study was collected in the outpatient clinic of a large cancer center. We used the Temperament Evaluation in Memphis, Pisa and San Diego - Münster Version (TEMPS-M) and recorded patient data.
Article Synopsis
- Alcohol use disorder (AUD) affects over 95 million people globally, has a significant hereditary component (50-60%), and can potentially be treated with low-dose ondansetron (AD04) targeting specific genetic and behavioral profiles.
- A phase III clinical trial was conducted with 303 individuals diagnosed with AUD, focusing on those with specific genetic variants and varying levels of drinking severity.
- Results showed that AD04 significantly reduced heavy drinking days by 46.7% compared to a 38.1% reduction in the placebo group, indicating its effectiveness in treating AUD in targeted populations.
Background: The increasing prevalence of alcohol use disorder (AUD) and the parallel surge in alcohol-associated liver disease (ALD) emphasize the urgent need for comprehensive alcohol management strategies. Low-dose ondansetron (AD04, a 5-HT3 antagonist) was shown recently to be a promising treatment for AUD with a specific genotypic profile (5-marker). The liver safety of AD04 has never been evaluated in subjects with AUD.
View Article and Find Full Text PDFA core principle in the pursuit of scientific knowledge is that science is self-correcting and that important results should be replicable. Hypotheses need to be reinforced, adjusted, or rejected when novel results are obtained. Replication of results confirms hypotheses and enhances their integration into scientific practice.
View Article and Find Full Text PDFBackground: Autonomic symptoms in alcohol withdrawal syndrome (AWS) are associated with a sympathetic-driven imbalance of the autonomic nervous system. To restore autonomic balance in AWS, novel neuromodulatory approaches could be beneficial. We conducted a pilot trial with percutaneous auricular vagus nerve stimulation (pVNS) in AWS and hypothesized that pVNS will enhance the parasympathetic tone represented by a reduction of pupillary dilation in a parasympatholytic pharmacological challenge.
View Article and Find Full Text PDF