Publications by authors named "O M Kalashnikova"
Background: Juvenile systemic lupus erythematosus (SLE) is a severe, life-threatening disease. However, the role of rituximab in managing juvenile SLE remains undefined, although early biological intervention may improve disease outcomes.
Aim: To assess the differences in the outcomes of different types of rituximab administration (early and late).
Initial Respiratory System Involvement in Juvenile Idiopathic Arthritis with Systemic Onset Is a Marker of Interstitial Lung Disease: The Results of Retrospective Cohort Study Analysis.
J Clin Med
June 2024
Article Synopsis
- Pulmonary issues in systemic juvenile idiopathic arthritis (SJIA) are uncommon but pose serious risks, with various known risk factors, including macrophage activation syndrome and specific immune responses.
- A study examined the characteristics and outcomes of SJIA patients with respiratory system involvement (RSI), finding that 25% showed signs of RSI at the onset, which was associated with more severe symptoms and complications.
- Among those with RSI, 10% later developed fibrosing interstitial lung disease (ILD), and patients showed a high prevalence of severe relapsed disease and a need for careful monitoring and management of their condition.
This work helps address recent calls for systematic water quality assessment in Central Asia and considers how nutrient and salinity sources, and transport, affect water quality along the continuum from the cryosphere to the lowland plains. Spatial and, for the first time, temporal variations in stream water pH, temperature, electrical conductivity, and nitrate and phosphate concentrations are presented for four catchments (485-13,500 km), all with glaciers and major urban areas. The catchments studied were: Kaskelen (Kazakhstan), Ala-Archa (Kyrgyzstan), Chirchik (Uzbekistan) and the Kofarnihon (Tajikistan).
View Article and Find Full Text PDFBackground: Systemic lupus erythematosus (SLE) is the most frequent and serious systemic connective tissue disease. Nowadays there is no clear guidance on its treatment in childhood. There are a lot of negative effects of standard-of-care treatment (SOCT), including steroid toxicity.
View Article and Find Full Text PDF