A comparative study of PMMA/PEG polymer nanocomposites doped with different oxides nanoparticles for potential optoelectronic applications.

PMMA/PEG and PMMA/PEG doped with SiO, TiO and AlO were fabricated using the solution-casting technique. The composites were characterized by X-ray diffraction and scanning electron microscopy (FE-SEM), which revealed that the amorphous nature of PMMA/PEG blend doped with AlO was hindered by the crystalline nature of those doped with SiO and TiO. The absorption of PMMA/PEG blend doped with AlO is higher, band gap energies were decreased from 4.

PI3K/AKT signaling activation by roflumilast ameliorates rotenone-induced Parkinson's disease in rats.

Parkinson's disease (PD) is the second most common progressive age-related neurodegenerative disorder. Paramount evidence shed light on the role of PI3K/AKT signaling activation in the treatment of neurodegenerative disorders. PI3K/AKT signaling can be activated via cAMP-dependent pathways achieved by phosphodiesterase 4 (PDE4) inhibition.

Capsaicin, The Vanilloid Receptor TRPV1 Agonist in Neuroprotection: Mechanisms Involved and Significance.

Hot peppers, also called chilli, chilli pepper, or paprika of the plant genus Capsicum (family Solanaceae), are one of the most used vegetables and spices worldwide. Capsaicin (8-methyl N-vanillyl-6-noneamide) is the main pungent principle of hot green and red peppers. By acting on the capsaicin receptor or transient receptor potential cation channel vanilloid subfamily member 1 (TRPV1), capsaicin selectively stimulates and in high doses defunctionalizes capsaicin-sensitive chemonociceptors with C and Aδ afferent fibers.

Protective effect of hot peppers against amyloid β peptide and brain injury in AlCl-induced Alzheimer's disease in rats.

Objectives: This study investigated the therapeutic effect of red hot pepper ( annuum) methanolic extract in induced Alzheimer's disease using AlCl in male rats.

Materials And Methods: Rats were injected with AlCl intraperitoneally (IP) daily for two months. Starting from the 2nd month of AlCl, rats received, in addition, IP treatments with extract (25 and 50 mg/kg) or saline.

Curcumin modulation of L-dopa and rasagiline-induced neuroprotection in rotenone model of Parkinson's disease.

Objectives: Parkinson's disease (PD) is one of the most incurable, chronic, and progressive neurodegenerative disorders Worldwide. Curcumin, a natural polyphenolic anti-oxidant compound, has a long history in traditional medicine. We investigate the effect of curcumin on brain oxidative stress, DNA fragmentation, and motor changes in rotenone-induced PD in mice.